Physiology & behaviorAnimalsHippocampusMaleHydrogen SulfideAntidepressive Agents
GDF11/TGFBR1 activation is essential for the antidepressant-like effect of H₂S: Role of suppressing the hippocampal cascade of necroptosis-neuroinflammation-Kynurenine pathway disorder.
Xiang Chen, Bo Wang, Yu-Hui Tang, Yi-Li Yi, Wei Zou, Xiao-Qing Tang, San-Qiao Yang
Published: 202610.1016/j.physbeh.2026.115227
Abstract
BACKGROUND: Depression remains a major global health challenge, and current treatments are suboptimal. Hydrogen sulfide (H₂S), an endogenous gasotransmitter, has antidepressant potential; however, its mechanisms remain incompletely understood. Unders…
Preview only. Read the full abstract at the source