Phytomedicine : international journal of phytotherapy and phytopharmacology
Multi-omics analysis and experimental verification reveal the role of dihydrocaffeic acid against 5-fluorouracil-induced intestinal mucositis.
Junjie He, Hengxiang Shen, Ziwei Ye, Chenchun Ding, Renjie Zuo, Zhenzhen Guo, Quan Liao, Hao Zhang, Guoyan Liu
Published: 202610.1016/j.phymed.2026.157837
Abstract
BACKGROUND: A common adverse effect of 5-fluorouracil (5-FU) in chemotherapy is intestinal mucositis (IM), which significantly impacts patients' quality of life. To date, no effective long-term treatment is available for IM. Dihydrocaffeic acid (DHCA…
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