Phytomedicine : international journal of phytotherapy and phytopharmacologyCarcinomaHepatocellularLiver NeoplasmsHumansAnimals
Seco-neokadsuranic acid A antagonizes SH3BP1 to suppress hepatocellular carcinoma progression through PPAR pathway activation.
Beixi Jia, Mengyang Liu, Xin Zhang, Mengyao Zhang, Haixia Cai, Haoyang Chen, Yihong Zhao, Yuefeng Bi
Published: 202610.1016/j.phymed.2026.157824
Abstract
BACKGROUND: The high mortality of hepatocellular carcinoma (HCC), driven by metastasis and drug resistance, underscores the need for novel therapeutics. The natural triterpenoid seco-neokadsuranic acid A (SA) shows promising antitumor activity; howev…
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