Phytomedicine : international journal of phytotherapy and phytopharmacologyHumansCell ProliferationAnimalsCell LineTumor
Unveiling poliumoside: A herbal-derived FAK kinase inhibitor with anti-proliferative and anti-metastatic efficacy.
Huiling Zhang, Yuna Shao, Di Lu, Chenkang Ma, Liying Zhang, Yang Yang, Jianjun Li, Yuanyuan Zeng, Jianjie Zhu, Jian-An Huang, Zhe Lei, Zeyi Liu
Published: 202610.1016/j.phymed.2025.157747
Abstract
Focal adhesion kinase (FAK) is an attractive therapeutic target overexpressed in numerous cancers. Despite extensive efforts, no FAK inhibitor has reached the market. Here, we identified poliumoside (Pol), a compound from Chinese herbs, as a novel FA…
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