Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAlkaloidsFatty AcidsMitochondria
Ramulus Mori (Sangzhi) Alkaloids (SZ-A) exert a renoprotective effect by activating PGC-1α to mediate fatty acid oxidation and mitochondrial homeostasis.
Jiawei Song, Jun Ye, Ning Sheng, Shengyuan Xu, Hongliang Wang, Yanfang Yang, Shan Chen, Jinlan Zhang, Yan Tang, Xinhua Xiao, Yuling Liu
Published: 202610.1016/j.phymed.2025.157743
Abstract
BACKGROUND: Chronic kidney disease (CKD), especially when comorbid with diabetes, represents a significant global health burden with limited therapeutic options. Ramulus Mori (Sangzhi) Alkaloids (SZ-A) is a natural alkaloid formulation approved in Ch…
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