Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsDNAMitochondrialSignal TransductionHeart Failure
Xin-Ji-Er-Kang alleviates chronic heart failure by suppressing mtDNA/cGAS-STING signaling through NR3C1-mediated MFN2 upregulation.
Rumeng Zhang, Jiamin Wu, Dingyan Wang, Keke Li, Yifan Hou, Ying Yu, Chaolong Jin, Chunmiao Wang, Shan Gao
Published: 202610.1016/j.phymed.2025.157714
Abstract
BACKGROUND: cGAS/STING signaling activation driven by mitochondrial DNA (mtDNA) release contributes to chronic heart failure (CHF) pathogenesis. Although the traditional Chinese medicine Xin-Ji-Er-Kang (XJEK) shows cardioprotective potential, its reg…
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