Phytomedicine : international journal of phytotherapy and phytopharmacologyFerroptosisChalconesHumansSp1 Transcription FactorReperfusion Injury
Licochalcone A promotes SP1/DNA-PKcs-dependent NHEJ repair to prevent ferroptosis and attenuate hepatic ischemia-reperfusion injury.
Min Li, Zhangqi Mao, Lulu Lu, Huanhuan Xu, Yi Guo, Chuhui Song, Jun Yang, Yingying Yu, Xuexian Fang
Published: 202610.1016/j.phymed.2025.157650
Abstract
BACKGROUND: Ferroptosis, an iron-dependent form of cell death driven by lethal lipid peroxidation, is implicated in various pathological conditions. Despite its clinical significance, the development of effective ferroptosis inhibitors remains challe…
Preview only. Read the full abstract at the source