Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsAnticonvulsantsBlood-Brain BarrierEpilepsyMice
Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline.
Xin Gao, Xinjia Li, Yuanteng Zheng, Lijie Xia, Haonan Li, Yuqing Li, Attila Sik, Kechun Liu, Meng Jin
Published: 202610.1016/j.phymed.2025.157636
Abstract
BACKGROUND: Epilepsy is a common neurological disorder that manifests as sudden abnormal electrical discharges and convulsions, affecting more than 70 million people worldwide. Current antiepileptic drugs (AEDs) can inhibit seizures, while long-term…
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