Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsMiceNF-E2-Related Factor 2EncephalitisHerpes Simplex
Rhoifolin prevents herpes simplex virus encephalitis by modulating SESN2 to regulate the Keap1/Nrf2 and AMPK/Nox pathways to inhibit neuro-oxidative damage in mice.
Wenhui Yang, Xi Chen, Danwen Wang, Longkang Liu, Hao Ma, Tong Wang, Huilin Zhu, Junyi Wang, Tonghui Ma, Peng Cao, Guangyi Cui
Published: 202610.1016/j.phymed.2025.157621
Abstract
BACKGROUND: Herpes simplex encephalitis (HSE), predominantly caused by herpes simplex virus type 1 (HSV-1), is a life-threatening central nervous system disease and the leading cause of sporadic encephalitis globally. Currently, the treatment for HSE…
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