Phytomedicine : international journal of phytotherapy and phytopharmacologyStomach NeoplasmsHumansGlycolysisHistonesCell Line
Brusatol inhibits gastric cancer by targeting P4HA2 and supressing glycolysis-driven histone lactylation.
Kaiyuan Zhang, Xiaochen Ni, Chuhang Wang, Jianing Guo, Wei Fan, Tao Jiang, Guangji Zhang
Published: 202610.1016/j.phymed.2025.157585
Abstract
BACKGROUND: Brusatol (BRU) is a bioactive derived from Brucea javanica. It has demonstrated anti-tumor effects in gastric cancer (GC). However, its role in regulating metabolic-epigenetic cross-talk remains poorly understood. PURPOSE: This study aime…
Preview only. Read the full abstract at the source