Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsLiver CirrhosisPPAR gammaHepatic Stellate CellsMice
Targeting DEP-1 to regulate ERK/PPARγ dephosphorylation: multi-omics unravels dehydrocavidine's mechanism for attenuating hepatic fibrosis.
Kunqi Zong, Kaicheng Du, Yuhang Li, Changwei Zheng, Zhulingzhi Kuang, Gaosheng Hu, Yumeng Wang, Zhihan Li, Dali Meng
Published: 202510.1016/j.phymed.2025.157570
Abstract
BACKGROUND: Hepatic fibrosis (HF) is a critical state in the pathological and physiological progression of chronic liver disease to cirrhosis. Dehydrocavidine (DC), a natural isoquinoline alkaloid from the folk hepatoprotective herb Corydalis tomente…
Preview only. Read the full abstract at the source