Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsNF-E2-Related Factor 2SilicosisAutophagyPulmonary Fibrosis
Brusatol modulates autophagy to ameliorate pulmonary fibrosis by targeting Nrf2 in silicosis.
Huimin Kang, Rou Li, Housheng Yang, Hanqin Wang, Aoxiang Hu, Guo Chen, Xiya Li, Shi Chen
Published: 202510.1016/j.phymed.2025.157566
Abstract
BACKGROUND: Silicosis is a progressive lung fibrosis caused by silica exposure, with impaired autophagic degradation of alveolar macrophages recognized as a key pathogenic mechanism. Brusatol (Bru), an active compound from traditional Chinese medicin…
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