Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsSphingolipidsMacrophagesMicePancreatitis
Chaihu shugan powder ameliorated chronic pancreatitis by reprogramming SMS2-mediated sphingolipid metabolism in M1 macrophages.
Xiaoyin Zheng, Yijing Long, Lu Li, Jiawang Li, Yiqin Wang, Hui Meng, Qi Qiu, Jing Chen, Hao Yang, Qing Xia, Chenxia Han, Dan Du
Published: 202510.1016/j.phymed.2025.157565
Abstract
BACKGROUND: Chronic pancreatitis (CP) lacks targeted therapies. Its pathogenesis involves macrophage polarization-activated pancreatic stellate cells (PSCs), with sphingolipid metabolism playing an emerging role. The traditional formula Chaihu shugan…
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