Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsGastrointestinal MicrobiomeMaleRatsSphingolipids
Sclareol alleviates synovial inflammation in knee osteoarthritis by regulating sphingolipid metabolism along the gut-bone axis.
Lishi Jie, Junnan Liu, Yujiang Liu, Kaijia Zhang, Xiaofeng Shen, Bo Xu, Wanbo Ji, Xiaoqing Shi
Published: 202510.1016/j.phymed.2025.157563
Abstract
OBJECTIVE: Sclareol(SCL) is a diterpene alcohol compound with anti-inflammatory, antibacterial, and antioxidant properties, and it has high oral bioavailability. However, its pharmacological effects in the field of knee osteoarthritis(KOA) remain unc…
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