Phytomedicine : international journal of phytotherapy and phytopharmacologyAbietanesToll-Like Receptor 4AnimalsSignal TransductionReperfusion Injury
Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4/NF-κB signaling cascade: A study integrating network pharmacology, bioinformatics, and experimental validation.
Chenxi Zhou, Zhexuan Yu, Tianxue Chen, Qianqian Chen, Yangyang Zhang, Jiawei Cai, Cenglin Xu, Li Yu
Published: 202510.1016/j.phymed.2025.157548
Abstract
BACKGROUND: Tanshinone IIA is the primary compound of Salvia miltiorrhiza, has neuroprotective and antioxidant properties. However, its anti-inflammatory role in cerebral ischemia-reperfusion injury is not well understood. PURPOSE: To determine wheth…
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