Phytomedicine : international journal of phytotherapy and phytopharmacologyChondrocytesSesquiterpenesAnimalsLactonesApoptosis
Atractylenolide III regulates Vitamin K1 metabolism to activate effector chondrocytes for ameliorating cartilage degeneration in KOA.
Weijian Chen, Jiacong Xiao, Yuehui Zhou, Jifeng Zhao, Jiasheng Tao, Zhilong Ye, Xiaodong Lin, Chao Lu, Yizhe Song, Chi Zhou, Jun Liu, Tao Jiang, Mingzhu Zeng, Chuanxi Zhao, Wengang Liu
Published: 202510.1016/j.phymed.2025.157537
Abstract
BACKGROUND: The treatment for early-stage knee osteoarthritis (KOA) mainly focuses on anti-inflammatory and analgesic, yet the effective regulatory methods to improve cartilage degeneration remains a significant challenge. PURPOSE: To explore the pot…
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