Phytomedicine : international journal of phytotherapy and phytopharmacologyCarcinomaHepatocellularAnimalsLiver NeoplasmsB7-H1 Antigen
Escin inhibits PD-L1 expression by suppressing the p38 MAPK/ERK signalling pathways and synergistically enhances PD-1 inhibitor efficacy in hepatocellular carcinoma.
Yue Yuan, Ping Wang, Shirong Chen, Zihan Cao, Suvash Chandra Ojha, Changfeng Sun, Gan Wang, Zenglu Wang, Jintao Gu, Jiefang Kang, Xiaochang Xue
Published: 202510.1016/j.phymed.2025.157532
Abstract
OBJECTIVE: Treatment with immune checkpoint inhibitors (ICIs) currently has limited efficacy in hepatocellular carcinoma (HCC). Combining ICIs could achieve optimal immunotherapy. We investigated the anti-tumour effects of escin in HCC, focusing on i…
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