Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsSepsisFlavonoidsSignal TransductionMice
Icariin rescues immune dysfunction in sepsis through RSK2-driven YAP-cGAS-IFN-β signaling activation.
Yuran Huang, Fupeng Wu, Tianle Zhan, Xinyue Cao, Weilian Bao, Guize Feng, Jiahui Ni, Yirui Wang, Haidong Li, Tongqin Chen, Keyuan You, Dong Wang, Xiaoyan Shen, Keyu Sun
Published: 202510.1016/j.phymed.2025.157524
Abstract
BACKGROUND: Sepsis frequently leads to an immunosuppressive phase with high risk of secondary infection and mortality. Icariin (ICA) exhibits various bioactivities, yet its role in sepsis-induced immunosuppression is unclear. PURPOSE: This study aime…
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