Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsProgrammed Cell Death 1 ReceptorSpleenAcetophenonesAnxiety
Paeonol alleviates PD-1 deficiency-induced anxiety-like behaviors through reversing the neurotransmitter metabolic disorders in spleen-brain axis.
Luyan You, Tongzheng Liu, Zhenjiang Yu, Xinyu Wang, Jichun Zhang, Xuenan Wang, Zifa Li, Hao Zhang, Minghui Hu, Xiang Zai, Qun Zhang, Kai Chen, Sheng Wei, Cui Lv, Xiwen Geng
Published: 202510.1016/j.phymed.2025.157518
Abstract
BACKGROUND: Anxiety are frequently observed in patients with programmed cell death-1 (PD-1) blockade therapy, which is related with the overactivation of the immune system. Paeonol was described to regulate immune function and relieve mood symptoms,…
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