Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsAutophagyNucleotidyltransferasesMicrogliaMice
Protocatechuic acid alleviates cGAS-STING-mediated neuroinflammation by enhancing microglial autophagy in mouse models of Parkinson's disease.
Wenjuan Rui, Zihan Chen, Shun Tao, Xiaoyan Yao, Wenting Xie, Dengli Qin, Zhihan Ye, Yuqing Wu, Lieying Fan, Sheng Li
Published: 202510.1016/j.phymed.2025.157493
Abstract
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuron loss and neuroinflammation. The cGAS-STING pathway-mediated innate immune inflammation has been implicated in PD pathogenesis, but its…
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