Phytomedicine : international journal of phytotherapy and phytopharmacologySTAT3 Transcription FactorTriple Negative Breast NeoplasmsHumansAutophagyAnimals
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer.
Dongning Zheng, Junfang Shu, Benjian Gao, Hailong Yu, Kemeng Liu, Meiling Zheng, Xiaoyan Liu, Gang Chen, Yangyi Lin, Qinlian Li, Yuhang Sun, Yuhang Zheng, Bo Li, Xiaoli Yang, Kai Wang
Published: 202510.1016/j.phymed.2025.157485
Abstract
BACKGROUND: Triple-negative breast cancer (TNBC) lacks effective therapeutic targets and exhibits high metastatic potential, resulting in poor prognosis. Both STAT3 signaling and pro-survival autophagy are well-established as critical drivers of TNBC…
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