Phytomedicine : international journal of phytotherapy and phytopharmacologyFerroptosisHumansCarcinomaHepatocellularLiver Neoplasms
Arachidonic acid induces ferroptosis in hepatocellular carcinoma via the SIRT5-ACSL4/LPCAT3/ALOX15 axis, leading to lipid peroxidation and mitochondrial dysfunction.
Peisen Xue, Jingting Zhang, Zhibing Wang, Ling Wu, Jincheng Tang, Renyi Yang, Wenhui Gao, Puhua Zeng
Published: 202510.1016/j.phymed.2025.157450
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is among the most common and lethal malignancies worldwide, characterized by profound metabolic reprogramming and poor prognosis. Ferroptosis, an iron-dependent death driven by lipid peroxidation, has recent…
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