Phytomedicine : international journal of phytotherapy and phytopharmacologyNaphthoquinonesHumansCarcinomaNon-Small-Cell LungLung Neoplasms
Unveiling plumbagin as a novel metabolic modulator to suppress ACC1-mediated de novo lipogenesis in non-small cell lung cancer.
Zhi-Hua Deng, Liang-Jun He, Shanshan Wei, Chang-Sheng Li, Ya Chen, Xin-Yi Ai, Chatchai Chaotham, Supat Jiranusornkul, Pei-Cheng Zhang, Zhuo Luo, Shang-Ping Xing, Jie Yang
Published: 202510.1016/j.phymed.2025.157438
Abstract
BACKGROUND: Targeting tumor metabolic reprogramming, particularly de novo lipogenesis (DNL) regulated by acetyl-CoA carboxylase 1 (ACC1), constitutes a promising therapeutic strategy. Non-small cell lung cancer (NSCLC) is a predominant subtype of lun…
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