Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsFerroptosisOsteoporosisOsteoclastsUbiquitination
Gnetol targeting of TNFAIP3 promotes SLC7A11 ubiquitination and ferroptosis in osteoclasts to ameliorate osteoporosis.
Xiaoming Peng, Weilun Zhao, Fayun Yang, Yuhang Wei, Yi Zhang, Shou Chen, Ji Yong Wei, Jianhua Huang, Yilin Teng, Gaofeng Zeng, Shaohui Zong
Published: 202510.1016/j.phymed.2025.157422
Abstract
Osteoporosis, a disorder characterized by excessive bone resorption due to hyperactive osteoclasts outpacing bone formation, remains a significant clinical challenge. Emerging evidence suggests that selectively inducing ferroptosis in osteoclasts rep…
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