Phytomedicine : international journal of phytotherapy and phytopharmacologyGefitinibGinsenosidesHumansCarcinomaNon-Small-Cell Lung
Membrane cholesterol-dependent dual VEGFR2/FGFR1 inhibition by ginsenoside Rg3 to overcome gefitinib resistance in NSCLC.
Min Jiang, Chao Hong, Wenkui Zou, Zheng Ye, Kexu Gu, Yaning Ren, Mingfang Li, Don Green, Tong Zhang, Yue Ding
Published: 202510.1016/j.phymed.2025.157421
Abstract
BACKGROUND: Drug resistance severely hinders the clinical application of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of non-small cell lung cancer (NSCLC). Notably, resistance caused by rare target mutatio…
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