Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsArtemisininsMicrogliaMiceMitochondria
Dihydroartemisinin alleviates sepsis-associated encephalopathy by reducing microglial iron accumulation and mitochondrial dysfunction via HIF1A/HMOX1 pathway.
Hailong Gong, Huifan Liu, Min Yuan, Guoqing Jing, Yun Xia, Jing Zuo, Huimin Zhou, Die Wu, Cheng Yang, Xing Wang, Delida Aidebaike, Xueke Du, Xuemin Song, Xiaojing Wu
Published: 202510.1016/j.phymed.2025.157413
Abstract
BACKGROUND: Sepsis-associated encephalopathy (SAE) refers to acute brain dysfunction caused by sepsis without direct central nervous system infection, in which microglia plays a pivotal role. Microglial ferroptosis is one of the key drivers of SAE. D…
Preview only. Read the full abstract at the source