Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsMitophagyMyocardial Reperfusion InjuryIon ChannelsMice
Lithospermic acid alleviates myocardial ischemia/reperfusion injury by inhibiting mitophagy via the Piezo1-PPP3/calcineurin-TFEB pathway.
Xin Chen, Honglin Xu, Zhongyang Yu, Shujin Pang, Ruixue Chen, Shangfei Luo, Xianmei Pan, Rentao Wan, Youfen Yao, Xiaoting Chen, Qiaorui Tan, Bin He, Yajuan An, Lingjun Wang, Yining Guo
Published: 202510.1016/j.phymed.2025.157402
Abstract
INTRODUCTION: Myocardial ischemia/reperfusion injury poses a human health threat, and lithospermic acid (LA) has shown potential as a therapeutic agent. OBJECTIVES: To investigate the preventive effects of LA and elucidate its modulation of Piezo-Typ…
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