Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsFemaleOvariectomyI-kappa B KinaseOsteoclasts
Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKKβ-mediated NF-κB p65 phosphorylation.
Kai Shi, Ying-Jian Wang, Shaoming Wang, Zhenhong Guan, Man Li, Ya-Nan Zhao, Wan-Chun Sun
Published: 202510.1016/j.phymed.2025.157401
Abstract
BACKGROUND: Excessive activation of osteoclasts can lead to excessive bone resorption, thereby causing bone loss diseases. Okanin, a flavonoid derived from Coreopsis tinctoria, has been reported to possess antibacterial, anti-inflammatory and antioxi…
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