Phytomedicine : international journal of phytotherapy and phytopharmacologyStomach NeoplasmsFerroptosisHumansPhospholipid Hydroperoxide Glutathione PeroxidaseFlavonoids
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hong Mei Hu, Jia Le Deng, Yan Pan, Zi Han Wang, Jing Zhang, Xin Yu Gu, Sheng Xian Fan, Ji Zhong Zhao
Published: 202510.1016/j.phymed.2025.157387
Abstract
Mounting evidence identifies cancer as the leading cause of death in diabetic patients, necessitating therapies that disrupt this pathological nexus. We demonstrate that the flavonoid breviscapine inhibits diabetes-accelerated gastric cancer through…
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