Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsOsteogenesisFracture HealingDinoprostoneCyclooxygenase 2
Shangke Jiegu tablet enhances callus formation during fracture repair by promoting angiogenesis-osteogenesis coupling via PTGS2-PGE2/EP4 axis.
Lin Chen, Chu Zhang, Xiaojie Li, Jingyuan Zhang, Jie Zou, Suya Zhang, Jing Zhang, Xueting Liu, Yudong Liu, Zhaochen Ma, Ying Liu, Na Lin, Jigang Wang, Yanqiong Zhang
Published: 202510.1016/j.phymed.2025.157382
Abstract
BACKGROUND: Bone fractures greatly limit patients' mobility and quality of life. Shangke Jiegu tablet (SJT), a Chinese patent drug, shows significant efficacy in fracture treatment, yet its molecular mechanism remains unclear. PURPOSE: This study aim…
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