Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsSarcopeniaMiceInsulin-Like Growth Factor IProto-Oncogene Proteins c-akt
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.
Xiaomin Wang, Liping Zhu, Ruoyutong Du, Ang Li, Na Li, Xiaoying Liu, Yin Zhang, Xiaoqin Liu, Qiong Wang, Chao Han, Chao Qu, Wei Zou, Jing Liu, Yanfu Wang
Published: 202510.1016/j.phymed.2025.157378
Abstract
BACKGROUND: Sarcopenia (SP) is characterized by progressive loss of skeletal muscle mass and function, and is a significant health burden in an aging society. Existing therapies have limited effectiveness. While ferroptosis plays a key role in sarcop…
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