Phytomedicine : international journal of phytotherapy and phytopharmacologyAnimalsColorectal NeoplasmsReceptorsG-Protein-CoupledDrugs
Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer.
Luxuan Guo, Jia Yi, Ao Zhang, Xiaoqing Zheng, Miao Wang, Fan Yang, Xianbin Kong, Jingyan Meng
Published: 202510.1016/j.phymed.2025.157312
Abstract
BACKGROUND: Immune checkpoint inhibitors (ICIs), particularly PD-1 antibodies, represent a breakthrough in colorectal cancer (CRC) treatment. However, their clinical efficacy remains limited by tumour-induced immunosuppression. Traditional Chinese me…
Preview only. Read the full abstract at the source