Phytomedicine : international journal of phytotherapy and phytopharmacologyFerroptosisAnimalsNF-E2-Related Factor 2DoxorubicinMale
Xin-Ji-Er-Kang modulates NRF2 to inhibit ferroptosis and attenuate doxorubicin-induced myocardial injury.
Si-Min Yang, Zhang-le Hu, Hui-Yu Jia, Pang-Bo Yang, Zhi-Wei Xu, Cong Ma, Sheng-Yong Luo, Wei Chen, Shan Gao
Published: 202510.1016/j.phymed.2025.157302
Abstract
BACKGROUND: Xin-Ji-Er-Kang (XJEK), a traditional Chinese medicine formulation, has shown protective effects in various murine models of cardiovascular disease. However, its potential mechanisms in mitigating drug-induced cardiotoxicity, particularly…
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