Phytomedicine : international journal of phytotherapy and phytopharmacologyFerroptosisArtesunateFemaleAnimalsSTAT3 Transcription Factor
Artesunate triggers ferroptosis in ovarian cancer via GP130-mediated IL-6/STAT3/OTUB1/SLC711 axis disruption.
Dengyun Nie, Han Zhang, Hua Wang, Weiwei Song, Donglan Yuan, Dandan Zhu, Guangyao Mao, Ting Guo, Mei Lin
Published: 202510.1016/j.phymed.2025.157269
Abstract
BACKGROUND: Ovarian cancer (OC) is highly malignant with suboptimal current therapeutic outcomes. Ferroptosis is a novel cell death mode. Artesunate (ART) has demonstrated relatively broad-spectrum anticancer effects recently, yet whether it can supp…
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