Phytomedicine : international journal of phytotherapy and phytopharmacologyFlavanonesHepatic Stellate CellsAnimalsCellular SenescenceGlycolysis
Baicalein Induces Hepatic Stellate Cell Senescence and Attenuates Liver Fibrosis via CEBPZ/p53/HK2-Mediated Glycolysis Inhibition.
Shuling Chen, Ruiqi Li, Caiyun Zhang, Jun Guo, Anyin Yang, Dawei Yang, Tianhao Mao, Hongli Liu, Hao Ren, Zihao Liang, Wei Chen, Changhua Yi, Qingfang Xiong, Dandan Yin, Xixuan Wang
Published: 202510.1016/j.phymed.2025.157222
Abstract
BACKGROUND: Liver fibrosis progresses to life-threatening cirrhosis, yet effective therapies remain limited. Baicalein (BA), a bioactive flavonoid, shows anti-tumor potential but its anti-liver-fibrotic efficacy is completely unexplored. PURPOSE: Thi…
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