Pharmacological research
Impaired PARP1-Dependent DNA Repair in MORC2 Mutations Drives Axonal Degeneration in Charcot-Marie-Tooth Disease Subtype 2Z and Spinal Muscular Atrophy-Like Neuromotor disorders.
Mengli Wang, Honglan Yang, Zhongzheng Li, Sen Zeng, Ke Xu, Binghao Wang, Yongzhi Xie, Qingping Wang, Zhuolin Su, Mingri Zhao, Yiti Zhang, Mujun Liu, Beisha Tang, Xionghao Liu, Ruxu Zhang
Published: 202610.1016/j.phrs.2026.108103
Abstract
MORC2 mutations are associated with a spectrum of neuromotor disorders, including Charcot-Marie-Tooth disease subtype 2Z (CMT2Z) and a spinal muscular atrophy (SMA)-like phenotype. However, the mechanisms underlying these conditions remain unclear. I…
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