Pharmacological research
PHGDH as a therapeutic node: Natural modulators from TCM, degradation pathways, and emerging TPD strategies.
Song-Song Shi, Yu-Dan Du, Si-Yi Chen, Wen Zhang, Guo-Wu Rao, Quan Zheng
Published: 202510.1016/j.phrs.2025.108079
Abstract
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a promising therapeutic target due to its critical roles in the pathogenesis of cancer and neurological disorders. Targeting PHGDH holds significant theoretical and translational potential for can…
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