Pharmacological researchAnimalsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaOrganoidsMitochondriaTriiodothyronine
Targeting PGC-1α axis rescues aberrant development from thyroid hormone defect in brain organoids.
Emanuela Bottani, Francesca Ciarpella, Benedetta Lucidi, Giulia Pedrotti, Chiara Santanatoglia, Eros Rossi, Enrica Cappellozza, Elisa De Tomi, Sissi Dolci, Giovanni Malerba, Giorgio Malpeli, Ilaria Decimo
Published: 202610.1016/j.phrs.2025.108071
Abstract
Thyroid hormone (T3) deficiency during central nervous system development leads to severe and often incurable human pathologies, including intellectual disability and motor dysfunction. Using murine dorsal forebrain organoids, we showed that T3 is re…
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