Pharmacological researchHumansKetamineDouble-Blind MethodMaleFemale
Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.
Zhuo-Ning Zhang, Xin-Yu Hao, Chen Cai, Li Sun, Zi-Yi Zhang, Miao Wang, Yi-Shuang Wu, Ying Wang, Jiang-Bei Cao, Yan-Hong Liu, Jing-Sheng Lou, Qiang Fu, Sheng-Li Jiang, Ru-Quan Han, Wei-Dong Mi
Published: 202510.1016/j.phrs.2025.108047
Abstract
This randomized, double-blind, parallel-group trial evaluated the efficacy of a single intravenous dose of esketamine (0.3 mg/kg) administered at anesthesia induction in reducing postoperative depression and anxiety among patients undergoing cardiac…
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