Pharmacological researchHumansSodium-Glucose Transporter 2 InhibitorsAnimalsMacrophagesDiabetes Mellitus
Pleiotropic effects of SGLT2 inhibitors: A focus on macrophage-mediated action.
Bing Shu, Xisha Chen, Zhonghao Liu, Huifang Tang, Bo Yang, Chengxiao Fu
Published: 202510.1016/j.phrs.2025.108046
Abstract
SGLT2 inhibitors, initially developed for type 2 diabetes management, have primarily demonstrated pleiotropic benefits in cardiovascular, renal, pulmonary, digestive and endocrine/metabolic, et al. Emerging evidence highlights their immunomodulatory…
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