Pharmacological researchColorectal NeoplasmsHumansAnimalsProto-Oncogene Proteins p21(ras)Fluorouracil
CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer.
Ruilin Wu, Yue Liu, Junwei Fu, Tianhua Zhou, Ronggui Hu, Bo Yang, Qiaojun He, Tao Yuan, Hong Zhu
Published: 202510.1016/j.phrs.2025.108027
Abstract
KRAS, the most frequently mutated oncogene in colorectal cancer (CRC), presents a formidable therapeutic challenge. While 5-fluorouracil (5-FU) and oxaliplatin remain the cornerstone of chemotherapy for KRAS-mutant CRC, their efficacy is frequently u…
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