Pharmacological researchHumansSignal TransductionReceptorCannabinoidCB2
Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists.
Jara Bouma, Elisa J M de Koning, Cas van der Horst, Sanjay Sunil Kumar, Barry J W van den Berg, Samuel R J Hoare, Matthias B Wittwer, Wolfgang Guba, Arne C Rufer, Uwe Grether, Mario van der Stelt, Laura H Heitman
Published: 202510.1016/j.phrs.2025.108021
Abstract
Studying biased signaling of G protein-coupled receptors (GPCRs) holds promise for the identification of ligands with a better therapeutic window. However, proper examination of biased signaling remains challenging by risking introduction of system o…
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