Pharmacological researchAnimalsVascular CalcificationReceptorAdenosine A2AOsteogenesis
Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation.
Yaqi Zhou, Dingwei Zhao, Qian Ma, Sujin Lee, Kangsan Roh, Yongfeng Cai, Jiean Xu, Qiuhua Yang, Qingen Da, Zhiping Liu, Kunfu Ouyang, Eric J Belin de Chantemele, Mei Hong, Clint L Miller, Rajeev Malhotra
Published: 202510.1016/j.phrs.2025.108012
Abstract
Vascular calcification (VC) is a major contributor to cardiovascular morbidity and mortality, particularly in patients with chronic kidney disease (CKD). Adenosine 2 A receptor (ADORA2A) is highly expressed in vascular cells and implicated in cardiov…
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