Pharmacological researchHumansCell ProliferationCell LineTumorEther-A-Go-Go Potassium Channels
KV11.1 (hERG1)-centered macromolecular membrane complexes regulate proliferation in B cell lymphomas and constitute novel pharmacological targets.
Cesare Sala, Jessica Iorio, Claudia Duranti, Alberto Montalbano, Laura Clara Grandi, Luciano Cascione, Markus Raderer, Francesco Bertoni, Annarosa Arcangeli, Andrea Becchetti
Published: 202510.1016/j.phrs.2025.107992
Abstract
K+ channel modulation is essential to regulate the Ca2+ signals that trigger T and B lymphocyte activation. The K+ channel complement is however deeply altered in cancer cells, as it is implicated in the neoplastic progression. We investigated the fu…
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