Pharmacological researchLupus ErythematosusSystemicAnimalsTh17 CellsHumans
ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE.
Yanli Zhang, Yu Zhen, Zhanchuan Ma, Xiaocong Wang, Hui Yu, Cong Hu, Sensen Su, Chang Shu, Guifeng Jia, Han Qin, Yueming He, Siyuan Ma, Huanfa Yi
Published: 202510.1016/j.phrs.2025.107991
Abstract
Th17 cells and interleukin-17A (IL-17A) drive the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Although myeloid-derived suppressor cells (MDSCs) promote the differentiation of Th17 cells, the epigenetic mechanisms rema…
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