Pharmacological researchHumansMajor Depressive DisorderAnimalsAntidepressive AgentsReceptors
Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities.
Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang, Peter Illes
Published: 202510.1016/j.phrs.2025.107989
Abstract
Major depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy. Recent studies have revealed that extra…
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