Protein expression and purificationViral Regulatory and Accessory ProteinsTrans-ActivatorsHumansHepatitis B virusProtein Isoforms
Expression, purification and functional validation of a cancer-associated isoform of the HBx protein from human hepatitis B virus.
Alexis Clavier, Santiago Gómez-Evain, Toshinobu Shida, Rubaba R Abanti, Franziska Hammerstein, Pavel Kielkowski, Mila Leuthold, Anne K Schütz
Published: 202610.1016/j.pep.2025.106842
Abstract
The human hepatitis B virus (HBV) causes hepatitis B, a liver infection that can be acute or chronic. HBV encodes four proteins, among which the X protein (HBx) plays a critical role in viral replication. During chronic HBV infection, in which the vi…
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