Progress in biophysics and molecular biology
Rewiring lipid Metabolism: The central role of CPT1 in metabolic dysfunction.
Dan Ni, Yuxuan Liu, Xiaofang Lin, Manqing Luo, Chuanhuan Deng, Jing Li, Pengfei Liang, Zhenguo Liu, Bimei Jiang
Published: 202510.1016/j.pbiomolbio.2025.11.002
Abstract
Carnitine palmitoyltransferase 1 (CPT1) serves as a critical gatekeeper in mitochondrial fatty acid oxidation and plays a central role in systemic energy homeostasis. The CPT1 family comprises three isoforms-CPT1A, CPT1B, and CPT1C-which exhibit dist…
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