Pharmacology, biochemistry, and behavior
The SIRT1-HMGB1 pathway in hippocampal microglia is involved in chronic heroin-induced cognitive impairment.
Chunlu Li, Yujie Wei, Dan Yin, Chuanrui Zhao, Guangkun Chen, Qian Wang, Mingjuan Shi, Yan Hong, Yixin Li, Baijuan Xia
Published: 202610.1016/j.pbb.2026.174155
Abstract
Recent studies have found that microglia-mediated hippocampal damage may be involved in cognitive impairment induced by chronic heroin treatment. However, its specific molecular mechanism remains unclear. This study explored the possible role of the…
Preview only. Read the full abstract at the source