Pharmacology, biochemistry, and behaviorAnimalsReceptorsOpioidmuAntidepressive Agents
Dual activation of 5-HT1A and μ-opioid receptors mediates dezocine's antidepressant effects in mice with comorbid pain and depression.
Qian-Qian Wei, Kun-Hong Zhong, Xiao-Ke Zhang, Liangxue Zhou, Qing Zhu, Junxu Li
Published: 202610.1016/j.pbb.2025.174136
Abstract
BACKGROUND: Pain-depression morbidity affects millions, but there are no effective treatments available. Dezocine is a clinically used opioid analgesic with complicated pharmacological mechanisms. Given this unique pharmacological profile and the cru…
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